cluckindan 21 hours ago

Sounds like it comes with an increased risk of stroke and cardiological issues, psychomotor agitation, anxiety, aggression, possibly even psychosis. Humans have noradrenaline regulation for a reason.

  • tsol 13 hours ago

    We'll have to see. There are a lot of natural and experimental painkillers that aren't used either because of side effects or more often because they just don't work consistently. It just so happens that so far the opioids are the only ones that can handle extreme pain. It's a hard problem to solve

  • elric 21 hours ago

    Does the article not consider those to be serious side effects then? What is considered serious?

    • cluckindan 18 hours ago

      In this case, I believe ”serious side effects” is referring to opioid addiction and physical dependency.

burnt-resistor a day ago

A new class of selective α2B-adrenoceptor antagonist.

raylad a day ago

It works by causing a release of noadrenalin.

Prediction: It will end up being used by the military and/or fighters to provide instantaneous muscle strength coupled with pain relief from overexertion.

  • harvie a day ago

    Isn't that just gonna keep the patients in constant fight-or-flight mode? Perhaps developing PTSD or something over time...

    • buran77 a day ago

      With soldiers it makes sense to use it explicitly to enforce the "fight" mode as needed. This can range from "occasionally in emergencies" to "all the time".

      But militaries have famously not cared about the long term health and well being of their forces past their active use. So any consequence of "long term fight mode" past victory day are just the cost of doing business.

      • phatskat 2 hours ago

        “Victory day” lol, I think the only one I’ve been alive for so far was “Mission Accomplished”

      • xeonmc 18 hours ago

        "Your injuries were not service related."

    • mvdtnz a day ago

      It's only constant if you constantly administer it

    • miningape a day ago

      Sounds like a secondary concern to me /s

tsoukase 21 hours ago

It is hard to beat morphine and its derivatives (eg fentanyl). In strict medical settings they are excellent analgetics and anxiolytics, safe with minor side effects. The only problem is when things go wary after the initial use (dependence etc).

M95D 20 hours ago

What about tolerance? Will it need increasing doses to be effective?

erickhill a day ago

Why is this written in such a way to only target cancer patients?

  • lmm a day ago

    Probably that's where the funding is available.

  • bitwize a day ago

    The class of patients most likely to require opioids over long periods of time?

    • delusional a day ago

      And a class disproportionately insensitive to long term negative side effects.

      • briangriffinfan a day ago

        I have GOT to find a way to describe more things like this.

kelseyfrog a day ago

How is it different from Imiloxan?